ABSTRACT
I. INTRODUCTION More or less specific noncovalent molecular interactions are ubiquitous in biological systems. Signal transduction such as hormone-receptor binding, transcription of hereditary information, enzyme substrate binding, and regulation of enzyme activity are only few examples. The effects of drugs in these systems can often be explained in terms of binding to receptors, enzymes, or ion channels. Even the bioavailibility of drugs is modified by complexation to constituents of exipients and food or intestinal fluids.
