ABSTRACT
However, both the nebulizer and the pMDI have limitations, in terms of both
the dose they can deliver and the ease with which they can be used. Thus, in the
late 1950s the dry powder inhaler (DPI) was added to the arsenal of aerosol
delivery techniques. By the early 1990s these three aerosol delivery modalities
had become established technologies and had been used widely across a range of
diseases and with a host of molecules.
