ABSTRACT
Thrombolytic agents are a group of proteins that dissolve intravascular thrombi. The discovery and use of these agents have transformed therapeutic options offered to patients with arterial and venous occlusions. Limb salvage, decreased morbidity and mortality, alleviation of postthrombotic symptoms, and the requirement for less invasive procedures are the potential benefits of therapy. The purpose of this chapter is to review the mechanisms of fibrinolysis and examine the various thrombolytic agents and their applications.
