ABSTRACT
Platelets and antiplatelet agents play an increasing role in the clinical practice and research efforts of vascular surgeons. The role of antiplatelet agents has been investigated in arterial thrombosis and embolism, occlusive and hemorrhagic strokes, angina and myocardial infarctions, venous thromboprophylaxis and pulmonary embolism, and recurrent stenoses in endarterectomized arteries and in arterial graft occlusions. Antiplatelet agents have been studied in the laboratory as a deterrent to thrombus formation, atherosclerotic plaque formation, and development of anastomotic hyperplasia in vascular grafts. It is now clear that the platelet plays a pivotal role in all of the above named processes. Our understanding of platelet function and ways to alter its activity therefore become important concerns for the vascular surgeon.
