ABSTRACT
Clinicianswho regularly care for patients with disorders of the neuromuscular junction (NMJ) realize the importance of understanding its anatomy and physiology. A working knowledge of the anatomy and physiology of the normal NMJ is obviously needed to fully understand the pathophysiology of disorders affecting this highly specialized structure. In addition, a full appreciation of its normal function also forms the basis for understanding the principles underlying diagnostic testing and the mechanisms of certain therapeutic interventions. A review of the clinically relevant aspects of the anatomy and physiology of normal neuromuscular transmission follows. A number of clinical examples are provided to illustrate the application of anatomic and physiologic concepts to the diagnosis and treatment of patients with NMJ disease.
