ABSTRACT
This chapter emphasizes the protective role of CP in various musculoskeletal disorders. To understand the relevance of VCP in differentiated tissue, Arhzaouy et al. inactivated it in the skeletal muscle of adult mice. PTL alleviated cancer cachexia and improves skeletal muscle characteristics in a cancer cachexia model. Castets et al. demonstrated that PKB/Akt and mTORC1 play crucial roles in regulating muscle homeostasis and maintaining neuromuscular endplates after nerve injury. Inhibition of TAK1 attenuate denervation-induced muscle wasting in adult mice Finally, TAK1 activity is upregulated during overload-induced skeletal muscle growth, and inactivation of TAK1 prevents myofiber hypertrophy in response to functional overload. The chapter argues that TAK1 is a key regulator of skeletal muscle mass and oxidative metabolism. To explore the molecular mechanism of skeletal muscle contusion repair through changes in the expression of ATG-related genes and proteins in SD rats with acute skeletal muscle contusion, Luo et al. selected six rats as the control group from 30 male SD rats.
