ABSTRACT
This chapter highlights the significance of CP and antioxidants as CP regulators/modulators for the TSE-EBPT in ophthalmic diseases. CP/ATG maintains mitochondrial quality control by eliminating persistent CBs in the degenerating RPE and ganglion cells during AMD. LAMP2 plays an important role in ATG and lysosomal function and its mutation is responsible for the pathogenesis of Danon disease, which can cause retinopathy. Fukushima et al. reported a case of Danon disease retinopathy, where they explained how LAMP2 dysfunction contributes to the pathogenesis of retinopathy. Ali and Paulsen hypothesized the role of Prolactin and Prolactin-inducible protein in the pathogenesis of primary acquired nasolacrimal duct obstruction. Although, the antioxidant NAC scavenged ROS significantly but it was inefficient in preventing LECs from premature senescence, suggesting that restoring CP/ATG and improving mitochondrial functions may be a potential strategy for the prevention of LECs senescence-related cataract.
