ABSTRACT
This chapter describes causes, symptoms, risk factors, complications, pathophysiology, stages, prevention, treatment, and the theranostic significance of CP in the TSE-EBPT of Pressure ulcer (PU). PU is an injury to skin and its underlying tissue such as skeletal muscle. Compression, composed of mechanical deformation of muscle and external load, leads to localized ischemia, unloading reperfusion and, hence, a PU in bedbound patients. Frequent debridement and antimicrobial dressings are needed to control the biofilm. Strategies to treat PU, include bed rest, pressure redistributing support surfaces, nutritional support, repositioning, wound care. The Bax and Bak alter the function of CP/ATG in PU, suggesting that manipulating CP/ATG and apoptosis are potential theranostic targets for the treatment and prevention of PU. Inhibition of the Akt and ERK1/2 enhanced ATG and/or apoptosis, suggesting that JAK2 may play a protective role in PU-induced muscular I/R injury by inhibiting CP/ATG and apoptosis through the Akt and ERK1/2 pathways.
