ABSTRACT
Nanomaterials provide possibilities for improving the realms of tissue culture and regenerative medicine by addressing the existing challenges. Self-assembled nanocarriers are often composed of peptides or amphiphilic block copolymers. Due to parity in size, nanomaterials are able to conjugate with biomolecules to produce stable hybrid systems with intriguing optoelectronic and targeting capabilities. Nanomaterials have provided excellent opportunities as imaging agents that, once combined with drug delivery, offer vast possibilities for developing multimodal theranostic platforms. Gold nanorods were wrapped within bovine serum albumin and cationic polymer polyethylenimine in order to confer stability and heightened transfection efficacy in HeLa cells in vitro. Nanofibers present a dense network to mimic the extracellular matrix (ECM) and are conducive for cells to adhere, grow, and differentiate into tissue. A homogeneous dendrimeric 3D scaffold simulating the ECM was developed by electrospun nanofibers of G3.5 polyamidoamine covalently bound to gelatin.
