ABSTRACT
Dendrimers are artificially synthesized highly monodisperse 3D macromolecules of defined geometry, size, surface properties, and molecular weights, with ordered branching patterns resembling a tree. The dendrimers typically are composed of three structural components: a core, repeated branching patterns radiating from the core, and the end groups. Commercially available polyamidoamine and polyethyleneimine dendrimers are always prepared through divergent techniques. The hydrophobic cores rich in nitrogen and oxygen atoms in dendrimers are capable of encapsulating poorly soluble drugs by hydrophobic interactions and H-bond formation. The polar terminal groups of the dendrimers can be conjugated with various molecules through covalent linkages. Dendrimers have shown promise as drug delivery system for targeting the posterior ocular compartment, which is required while treating conditions like age-related macular degeneration, diabetic retinopathy, and posterior uveitis. The transdermal route is a noninvasive way of drug delivery, with high compliance and maintenance of uniform drug concentration in blood.
