ABSTRACT
Nucleic acids and their analogues, polynucleotides, are polymers built from the chains of nucleotides. Obviously, the amount of the molecular mass of nucleic acids and polynucleotides and their great possibilities for intermolecular interaction can explain the fact that in some cases they were kept in place by the carrier due to adsorption forces. Nevertheless, most studies explore the possibility of forming a covalent bond between the ligand and the carrier. In most cases such polymer compounds are used as affinity sorbents. As different from obtaining polymeric derivatives of mononucleotides, most studies on synthesis of the systems “polymer carrier–polynucleotides (or nucleic acid)” are devoted specifically to the binding of an unmodified ligand. Immobilization of polynucleotides and nucleic acids, into which additional functional groups were introduced, was used less often.
