ABSTRACT

Acanthosis nigricans occurs in bowel and bronchial malignancies as well as some lymphomas. Twenty percent of all cases of dermatomyositis are associated with underlying malignancy of the bronchus, breast, stomach, and ovary. Scleroedema occurs in diabetics, sclerodactyly is a manifestation of scleroderma. Other skin disorders occuring in diabetes include: diabetic dermopathy, necrobiosis lipoidicum, abscesses, boils, and carbuncles. Eruptive xanthomata are due to hypertriglyceridaemia seen in poorly controlled diabetes. Stevens-Johnson syndrome is a severe form of erythema multiforme with lesions occurring in the mouth, conjunctiva, anal, and genital regions. Severe pruritis occurs in dermatitis herpetiformis, which is associated with a papulovesicular rash affecting the extensor surfaces and the very high possibility that the patient has coeliac disease. Perforating foot ulcers are a feature of diabetes mellitus, leprosy, and syphilis. They are trophic ulcers which occur in an insensitive foot as a result of neuropathic involvement by the disease process.