ABSTRACT
Over the years a myriad of terms with conflicting definitions have arisen in the area of drug combination experimentation. Therefore, our first task will be to arrive at a set of terms and definitions that will define our problem:
Addition — the term we will use to describe the effects when we examine two drugs in combination and the response is what we expect under our null hypothesis of no drug interaction
Potentiation — the term that will be used to describe one alternative hypothesis; that is, when the two drugs are used in combination, it takes less of each drug to see the same effect than if the drugs were additive
Antagonism — the term that will be used to describe the other alternative hypothesis; this occurs when it takes more of each drug used in the combination to see the same effect than if the drugs were additive
