ABSTRACT
Syngeneic controls were included DA liver into DA recipients and PVG liver into PVG recipients. The results showed that the nonrejection of DA liver by PVG and F1 recipients was not due to a failure of the host to initiate an anti-graft response, but rather to the termination of the rejection reaction at an early stage in PVG and at a more advanced stage in the F1, hybrid. Biopsy specimens from grafted livers were taken at laparotomy and immediately fixed in buffered 10% formalin. The tissues were embedded in paraffin and sections were stained with hematoxylin and eosin. DA liver transplanted orthotopically into BN recipients was acutely rejected in seven out of eight rats, with one animal showing chronic rejection. In acute rejection, there is marked swelling of portal tracts caused mainly by edema and cellular infiltration. The cells are mononuclear and mostly of histiocytic origin, with occasional lymphocytes and large pyroninophilic cells.
