This chapter focuses on the problems of diabetes mellitus in America. Diabetes mellitus is a clinical disorder of major medical significance. Glucose intolerance can be separated into three clinical classes: diabetes mellitus, impaired glucose tolerance, and gestational diabetes. Insulin-dependent diabetics have a lack of pancreatic insulin and are dependent upon daily injections of insulin to control blood glucose levels, avoid ketotic coma, and stay alive. Racial and ethnic considerations, geography, the type of diabetes, and the age of the patient are all factors which affect the appearance of diabetes mellitus. The race of a population has an important effect on the incidence of diabetes mellitus. Diabetic patients suffer from the symptoms and complications associated with diabetes and the diabetic population has a lower life expectancy than the general population. Injection of insulin with the use of a needle and syringe is the most common and convenient method for a diabetic patient to receive insulin.