ABSTRACT
This chapter provides a brief overview of the various types of stimulations. It explains growth factors, mechanical, thermal, and electrical stimuli. The chapter discusses the biology of cell rejection and the outcomes that are associated with it. It describes the uses of stem cells in tissue engineering and build on the different kinds of stimuli associated with physical interaction. The chapter also discusses some of the applications and technologies that are being used for the engineering of tissues and organs. It introduces an overview of the vast amount of stimulatory influences that are being used in therapy. Like mechanical and electrical therapy, thermal stimulation has also shown promising results. It is used as a vital tool in treating many diseases including osteoarthritis, a disease that affects a clear majority of elderly people. The main goal of heat shock stimulation therapy is to promote and enhance differentiation in Mesenchymal stem cells and other co-factors necessary for maturation of cells.
