ABSTRACT
The central nervous system (CNS) is exquisitely sensitive to hypoxia, so it is not surprising that changes in neuropsychological function might occur at high altitude. A realistic and important consequence of hypoxemia on the CNS is how it might accelerate fatigue. It is clear that hypoxia has dramatic effects on the central nervous system that are mediated, to a large extent, by the activity of ion channels. Acute hypoxia has effects on cerebral visual and auditory processing capabilities. Visual processing capability is commonly measured by using visual evoked potentials. The effect of high altitude exposure on auditory capabilities has been measured by means of auditory sensitivity, auditory evoked potentials, and auditory brainstem responses. Given concerns about the effects of acute hypoxic exposure on both short- and long-term cognitive function, an important question that arises is whether any such effects can be mitigated by the use of supplemental oxygen.
