ABSTRACT
The initial emphasis in engineering soft tissue replacement was focused on developing and using biodegradable synthetic materials, such as poly-L-lactic acid, polycaprolactone, polyglycolic acid, and other polymers, to aid in extracellular matrices production. Existing approaches to soft tissue replacement and regeneration typically rely on autologous tissue or synthetic implants, or a combination of both. Soft-tissue replacement can be classified into space filler; mechanical support; and fluid carrier. Damage done to the middle ear would fall under hard tissue replacement because it would involve the bones used for conduction. Prospective advances should focus on soft tissue replacements that can be vascularized either pre-implantation vascularization or post-implantation vascularization. In the human body, soft tissues are found all over and they refer to tissues that connect, support, and surround organs and structures. Muscle tissue functions by transforming chemical energy into mechanical energy. Fibrous tissue is mainly composed of fibroblast cells, densely packed collagen fibers, and elastin.
