ABSTRACT
Nitrogen-containing compounds, both cyclic (triazines) and acyclic (triazenes), have crucial roles in medicinal chemistry and pharmaceutical research. This chapter discusses the chemistry of triazenes and triazines and also highlights some of the recent advances and diversity possible with these types of structural frameworks. Triazenes also have a tendency to surprise medicinal chemists with new reaction pathways and increasing applicability. Triazenes, which are concealed diazonium salts, can be used to link functionalized arenes and amines to generate various heterocyclic structures. A continuous-flow protocol for the synthesis of triazenes is followed by diazonium salts generation and subsequent conversion into their masked or protected triazene derivatives using secondary amine. Sym-triazines have been documented for their antitumor, antimicrobial, and anticancer actions. S-triazine derivatives based quinoline shows a wide range of biological activity. The synthesized compounds are evaluated for antimicrobial activity against a variety of bacterial and fungal strains, and some of these compounds have shown significant antibacterial and antifungal activity.
