ABSTRACT
Nausea and vomiting (motion sickness) Ordinarily preceded by feelings of discomfort and uneasiness, nausea and vomiting are the principal results of motion sickness. These events are controlled by an emetic center in the brain that is influenced by stimuli from peripheral sites, from a so-called chemoreceptor trigger zone (CTZ) in the brain, or from the cortex of that organ. Antiemetics usually function by blocking these stimuli. Antihistamines-dimenhydrinate, for example-prevent peripheral stimuli from reaching the emetic center and are therefore particularly useful in cases of motion sickness or inner ear dysfunction. Anticholinergics, such as scopolamine, are also effective.
