ABSTRACT
Methods for separating and categorizing the components of complex mixtures are crucial for the biological sciences, as is illustrated by the numerous projects that now deal with genomic or proteomic analysis. This has accelerated the development of high-resolution and high-throughput separation methods, such as capillary electrophoresis for DNA sequencing and two-dimensional gel electrophoresis for the mapping of proteomic libraries. The outcome of such work has been the creation of molecular catalogs that map genes in genomes and that characterize proteins with respect to their size, charge, and abundance. This information can, in turn, be used to help our understanding of the biological processes in health and disease.
