ABSTRACT
Heparin-induced thrombocytopenia (HIT) is caused by heparin-dependent antibodies that usually recognize multimolecular complexes of platelet factor 4-heparin (PF4-H). HIT can be viewed as a clinicopathologic syndrome (Warkentin et aI., 1998). This implies that a diagnosis ofHIT should be based on two criteria: (1) clinically evident abnormalities, most commonly, thrombocytopenia with or without thrombosis (see Chap. 3), and (2) detection of HIT antibodies. In some ways, HIT resembles another clinicopathologic disorder, the antiphospholipid antibody (lupus anticoagulant) syndrome (Table 1).
