ABSTRACT

This chapter focuses on the measurement of elemental constituents in Cannabis vaping liquids and aerosols by inductively coupled plasma mass spectrometry (ICP-MS). There are many reports on elemental constituents of aerosol produced by Electronic Nicotine Delivery Systems (ENDS) in peer-reviewed literature with limited utility unfortunately due to some very poor analytical practices. The chapter discusses single quadrupole and triple quadrupole ICP-MS instruments for ENDS and Electronic Cigarette Delivery Systems (ECDS) liquid and aerosol analyses for metals and metalloids as they are the most commonly used ICP-MS instrumentation in modern analytical labs. For the analysis of ENDS and ECDS liquids and aerosols, a relatively low flow concentric nebulizer designed for approximately 400µL per minute delivery is recommended. The chapter also address best practices and common pitfalls that will result in higher quality analyses for informational and regulatory purposes.