ABSTRACT
Oxygen is the most abundant element in the Earth’s crust, and the second most abundant in the human body. The oxygen element is very reactive and can combine to form compounds with almost all other known elements, water being the most abundant and vital. Since uptake of Oxygen from the air is the essential purpose of respiration, oxygen supplementation is regularly used in medicine to increases oxygen levels in the blood and to decrease resistance to blood flow in many types of diseased lungs. Magnetic resonance acquisition with multiple quantum filter preparations can thus be used to probe the environment of these atoms and provide new information on materials and tissues that cannot be detected with conventional single quantum coherence acquisitions from 1H or 17O nuclear magnetic resonance. Although oxidative metabolism is the dominant source of energy for skeletal muscle, there was only very limited research in 17O magnetic resonance spectroscopy in muscle so far.
