ABSTRACT
Genotoxicity is a major cause of cancer. Genotoxins damage the DNA or the chromosomal structure causing mutations. It can be through chemicals or radiation. The damage to somatic cells leads to various diseases including cancer, and the damage to the germ cell leads to heritable diseases. Chemicals that damage DNA which leads to mutation or cancer are termed genotoxic. Toxicological studies have undergone a noteworthy evolution in the previous decade, with improved identification and understanding of genotoxins. This improved knowledge will enable the prevention of the damage caused to DNA by these genotoxic agents. In this chapter, the mechanism of genotoxicity and the importance of genotoxic studies are discussed.
