ABSTRACT
Engineered nanoparticles (NPs) are extensively used in diverse technologies, but their distinctive properties might cause adverse health effects. By reviewing recent in-vitro and in-vivo genotoxicity studies, a thorough discussion has been presented in this chapter about the potential mechanisms of genotoxicity induced by engineered NPs.
This chapter focuses on the various factors that may influence genotoxic response inclusive of the physicochemical properties and other experimental conditions. The widely used assays for genetic toxicity assessment are the Comet assay, the micronucleus assay, the chromosome aberrations test and the bacterial reverse mutation assay.
The merits and the prospective problems associated with the methods mentioned above have been discussed thoroughly and implications have been put into the open to call for appropriate methodologies to be employed for the exploration of genotoxic effects of engineered NPs by in-vitro and in-vivo methods.
