ABSTRACT
The necessity of a quantitative method for the estimation of circulating endothelial cells was obvious at first sight. Such a method would represent a direct indicator of a vascular lesion avoiding morphological examination of the vessel wall. The model of electrically induced and thermometrically indicated thrombosis in the rat’s carotid artery avoided the disadvantage but excessive damage to the vessel produced a situation dissimilar to clinical thrombosis. The indication in the latter method was based on blood extravasation from mesenteric vessels severed in a standard way and followed by hemoglobin photometry. A hypothesis is suggested that the residual thrombus represents the hemostatic, i.e., defensive component of thrombus formation related to the damage by vessel manipulation. In most experiments oral route of administration by gavage was used 1 h in advance of thrombus induction, if not otherwise specified.
