ABSTRACT
The story of acetylsalicylic acid began to unfold a long time ago. Since its introduction to the market under the name Aspirin in 1899 by Bayer, it has been one of the most effective nonsteroid anti-inflammatory drugs, also classified by pharmacologists as analgesics-antipyretics. Its range of indications is fairly wide and the drug was for many years and still is one prescribed and taken in the largest quantities. In 1968, the effectiveness of acetylsalicylic acid was also demonstrated in an animal model. In 1971 Vane demonstrated that the drug inhibits tissue cyclo-oxygenase while Smith and Willis described the same effect in platelets. In vitro effects are generally used in the screening of new antithrombotic drugs. It is well known that a tiny fraction of drugs effective under such conditions is clinically useful.
