ABSTRACT
After an attempt to look at thrombogenesis in a more integrated way taking into account particularly the still relatively neglected role of the vascular wall and emphasizing the multifactorial character of the process, the author introduces a novel system of biomodels constituting an integral battery of tests. The use of various tests as described in the literature in testing antithrombotic activity was surveyed including the results, if available, with the novel battery of tests used in the author’s laboratory. Throughout the text, the importance of animal models for the prediction of clinical use, dosages, and combinations of antithrombotics was emphasized. The in vitro tests and biochemical studies, however highly estimated as instruments of deeper knowledge, are not recommended for such prediction purposes and may be misleading without the necessary interface of biomodels.
