ABSTRACT
The processes of multiplication and death of irradiated cells also contribute to various changes because when a cell dies, all its lesions disappear, and when a cell divides in two, each lesion from the mother cell is distributed with certain probabilities between the daughter cells. Intracellular lesions induced by irradiation may be interpreted as discrete marks attached to a cell. As a rule, mathematical models of cell population kinetics determine the fate of a cell at the end of mitotic cycle. The typical example of the opposite situation is the survival of Chang liver cells irradiated during different stages of their growth in cell culture. The biological meaning will be unchanged if we consider only one target in a given cell instead of numerous identical targets and consequently confine ourselves to using the multihit-one target model. Continuous Markov processes and stochastic differential equations were applied for the analysis of the interphase death of cells exposed to radiation.
