Today, automatic titrators, automatic analyzers which incorporate instrumental designs and concepts, and automatic samplers which are attached to traditional instruments, are commonplace. Even complex sample preparation schemes involving sample dissolution and extraction utilize robotics to help streamline the procedures. In this chapter, the authors discuss the design and theory of automatic titrators, the Technicon Auto Analyzer,* flow injection analyzers, and robotics. When a large number of titrations is part of a laboratory’s daily workload, it is possible for the laboratory to employ a partially automated or even a fully automated system. This system may be something simple, such as a unit that automatically refills the buret, or refills the buret with the use of a vacuum bulb, after a titration. The Technicon AutoAnalyzer, developed in the late 1950s and early 1960s, represents the widely used analysis system that is based on “segmented” flow.