ABSTRACT
A great number of important biochemical reactions are related to the transfer of electrons, protons and other charged species between two localized states in macromolecules. In non-adiabatic reactions, the change of the structure of the reactants and the macromolecule in the neighborhood of the reaction zone occurs along with a change of the electron states of the reactants. A peculiar feature of protein molecules is their complicated spatial structure which is due to interactions between the side groups of various portions of the polypeptide chain. These interactions provide various configurations called conformational states of the macromolecule. The chemical bond A-B may have much greater vibrational frequency and the structure becomes more rigid. Therefore the reorganization of this group in the subsequent chemical transformation is insignificant and does not create a great activation barrier. The concept of electron-conformational interactions is widely used for description of the influence of the conformational dynamics on chemical charge transfer reactions in macromolecules..
