ABSTRACT
Plasmablastic differentiation can be found in wide range of large B-cell lymphomas, most of which are associated with either HIV and/or human herpesvirus 8 (HHV8 also known as Kaposi sarcoma–associated herpesvirus [KSHV]). They include plasmablastic lymphoma (PBL, oral mucosa type), plasmablastic lymphoma with plasmacytic differentiation, primary effusion lymphoma (PEL); extracavitary PEL, HHV8+ plasmablastic microlymphoma, large B-cell lymphoma arising in HHV8-associated multicentric Castleman disease (MCD), germinotropic lymphoproliferative disorder (GLD), and ALK+ large B-cell lymphoma (LBCL) [1–7]. Those lymphomas are clinically and morphologically heterogeneous, with features overlapping with other lymphomas/hematopoietic tumors. PEL is discussed in Chapter 43.
