ABSTRACT
Hodgkin lymphoma is divided into classic Hodgkin lymphoma (cHL) and nodular lymphocyte predominant Hodgkin lymphoma (NLPHL; Figure 26.1) [1–6]. cHL is a B-cell neoplasm characterized by the presence of Reed-Sternberg (R-S; Figure 26.2) cells and an accompanying polymorphic inflammatory infiltrate with eosinophils, histiocytes, small lymphocytes, and plasma cells. Based on the proportion of neoplastic cells (R-S cells and Hodgkin cells), the inflammatory background, and the amount of fibrosis, cHL is subdivided into four major subtypes: nodular sclerosis, lymphocyte-rich, mixed cellularity, and lymphocyte-depleted [1]. The incidence of cHL has a bimodal pattern, with the highest incidence seen in young patients and a second peak >60 years old.
