ABSTRACT
Nodular lymphocyte predominant Hodgkin lymphoma (HL) (NLPHL) is a monoclonal B-cell neoplasm characterized by the presence of scattered large atypical CD20+ lymphocyte predominant (LP) cells also referred to as “popcorn cells”, formerly known as L&H cells (lymphocyte and histiocyte cells) and a distinct nodular pattern on low magnification [1–8]. NLPHL involves most often peripheral lymph nodes (cervical, axillary, or inguinal lymph nodes), sparing usually mediastinal and axial lymph nodes. Mesenteric lymph node involvement can be seen but is rare. Bone marrow (BM) involvement is also rarely seen in NLPHL.
