ABSTRACT
Joseph Priestly first discovered Nitric Oxide (NO), a simple diatomic molecule having an N–O bond in 1772. Bioimaging is one possibility to trap NO by combining with other microscopic and spectroscopic instruments, such as chemiluminescence, amperometry, etc. There are two commercially available organic molecule–based sensors for bioimaging of NO by making a triazole ring. For the fluorescent effect, intensity enhancement is greater over the quench for the monitoring substance. They are developing metal-based fluorophore complexes, reacting them with NO, and studying the fluorescence that shows a diminished effect on NO binding to the metal center. Due to high precision in NO detection (in micro-level), metal complexes are employed as important component in biomedical NO sensor design. It was observed that NO has excellent therapeutic properties against bacteria and prevents thrombosis. Copper-based NO sensors are most important as they give have broad in vivo and in vitro applications with a larger period in sheep and rabbits.
