ABSTRACT
Dibrompropamidine is an antibacterial agent used for topical therapy. It is active against streptococci and staphylococci, including penicillin-resistant strains. It also has some activity against gram-negative microorganisms. In pharmaceutical products, dibrompropamidine is usually employed as dibrompropamidine isethionate. Three patients sensitized to dibrompropamidine were reported from Norway. Exudation and spreading erythema was followed by an acute itchy maculopapular dermatitis on the upper thorax and distal parts of the arms, with progressive dissemination to proximal parts of the legs. Patch testing with the cream and its ingredients showed positive reactions to the cream ‘as is’ and to dibrompropamidine 5%, 1%, 0.5% and 0.15% in petrolatum.
