ABSTRACT
Fepradinol is a phenylethanolamine derivative and nonsteroidal anti-inflammatory drug (NSAID) with analgesic, antipyretic and anti-inflammatory properties. Fepradinol is considered an adrenergic compound, due to its structural similarity with other α-adrenergic drugs, and is unrelated to the ‘classic’ NSAIDs such as ibuprofen and ketoprofen. Several case reports and small case series of allergic contact dermatitis and one of photoallergic contact dermatitis from topical use of fepradinol have been reported. Three men and a woman, ages ranging from 48-70 years, developed allergic contact dermatitis after having used 6% fepradinol spray to various parts of the body for 6 days to 10 weeks. In the period 1996-2001, in 2 hospitals in Spain, 3 patients were diagnosed with contact allergy and zero with photocontact allergy to fepradinol. Three patients sensitized by oral pseudoephedrine (causing generalized dermatitis) and two from phenylephrine in eye drops cross-reacted to fepradinol.
