ABSTRACT
Framycetin is an aminoglycoside antibiotic. It is apparently used only in topical pharmaceutical preparations, notably for the eyes and ears, most often as framycetin sulfate. This chapter provides monographs of framycetin which have caused contact allergy/allergic contact dermatitis. The monographs present: identification section; contact allergy (general population, patients with dermatitis, case reports and case series); cross-reactions; patch test sensitization; photocontact allergy; and immediate contact reactions (contact urticaria). The identification section presents IUPAC names, synonyms, CAS and EC numbers, structural and chemical formulas, Merck Index monographs, and advises on patch testing. Framycetin is widely used in ointment and tulle for the treatment of wounds and leg ulcers, in a combination preparation with a corticosteroid in an ointment frequently used for pruritus ani and hemorrhoids and in eardrops and nose spray. The chapter also covers an extensive amount of information to benefit dermatologists, allergists, and all others interested in drug allergy.
