ABSTRACT
This chapter provides monographs of hydrocortisone butyrate which have caused contact allergy/allergic contact dermatitis. The monographs present: identification section; contact allergy (general population, patients with dermatitis, case reports and case series); cross-reactions; patch test sensitization; photocontact allergy; and immediate contact reactions (contact urticaria). The identification section presents IUPAC names, synonyms, CAS and EC numbers, structural and chemical formulas, Merck Index monographs, and advises on patch testing. Intradermal testing with hydrocortisone butyrate may reveal additional cases of sensitization not picked up by patch testing. Hydrocortisone butyrate was suggested as a useful screening agent for corticosteroid allergy in 1986, but was later replaced with tixocortol pivalate and budesonide. The chapter also covers an extensive amount of information to benefit dermatologists, allergists, and all others interested in drug allergy.
