ABSTRACT
Isoconazole is an azole antifungal drug that is used in the treatment of dermatomycoses and vaginal Candida infections. In pharmaceutical products, both isoconazole and its salt isoconazole nitrate may be employed. In the period 1990 to 2014, in Leuven, Belgium, 148 patients suspected of iatrogenic contact dermatitis were tested with isoconazole 2% pet and there were 8 (5.4%) positive reactions. In the period 1976-1988, 13 cases of allergic contact dermatitis to imidazole antifungal preparations were seen in a private dermatological practice in Saverne, France, and 2 in the Universite Catholique de Louvain, Belgium. In a literature review up to 1994, the authors identified 105 reported patients who had a positive patch test reaction to at least one imidazole derivative, ranging from 51 reactions to miconazole to one reaction each to bifonazole and enilconazole. Statistically significant associations have been found in patient data between miconazole, econazole, and isoconazole; between isoconazole and tioconazole.
