ABSTRACT
Ketoconazole is a synthetic derivative of phenylpiperazine and an imidazole-type antifungal with broad fungicidal properties and potential antineoplastic activity. Ketoconazole is indicated for the treatment of superficial fungal infections and the following systemic fungal infections: candidiasis, chronic mucocutaneous candidiasis, oral thrush, candiduria, blastomycosis, coccidioido- mycosis, histoplasmosis, chromomycosis, and paracoccidioidomycosis. This chapter provides monographs of ketoconazole which have caused contact allergy/allergic contact dermatitis. The monographs present: identification section; contact allergy (general population, patients with dermatitis, case reports and case series); cross-reactions; patch test sensitization; photocontact allergy; and immediate contact reactions (contact urticaria). The identification section presents IUPAC names, synonyms, CAS and EC numbers, structural and chemical formulas, Merck Index monographs, and advises on patch testing. The chapter also covers an extensive amount of information to benefit dermatologists, allergists, and all others interested in drug allergy.
