ABSTRACT
Lactic acid is a normal intermediate in the fermentation (oxidation, metabolism) of sugar. It may be used in topical drugs, notably with salicylic acid in collodion for the treatment of warts. It is also applied with calcium chloride, magnesium chloride, dextrose monohydrate, sodium chloride, and sodium bicarbonate in replacement solutions in Continuous Renal Replacement Therapy to replace plasma volume removed by ultrafiltration. This chapter provides monographs of lactic acid which have caused contact allergy/allergic contact dermatitis. The monographs present: identification section; contact allergy (general population, patients with dermatitis, case reports and case series); cross-reactions; patch test sensitization; photocontact allergy; and immediate contact reactions (contact urticaria). The identification section presents IUPAC names, synonyms, CAS and EC numbers, structural and chemical formulas, Merck Index monographs, and advises on patch testing. The chapter also covers an extensive amount of information to benefit dermatologists, allergists, and all others interested in drug allergy.
