ABSTRACT
This chapter provides monographs of levobunolol which have caused contact allergy/allergic contact dermatitis. The monographs present: identification section; contact allergy (general population, patients with dermatitis, case reports and case series); cross-reactions; patch test sensitization; photocontact allergy; and immediate contact reactions (contact urticaria). The identification section presents IUPAC names, synonyms, CAS and EC numbers, structural and chemical formulas, Merck Index monographs, and advises on patch testing. Levobunolol, the L-isomer of bunolol, is a naphthalenone and non-cardioselective ß-adrenergic receptor antagonist with anti-glaucoma activity. Levobunolol is indicated for lowering intraocular pressure in patients with chronic open-angle glaucoma or ocular hypertension. In pharmaceutical products, levobunolol is employed as levobunolol hydrochloride. The chapter also covers an extensive amount of information to benefit dermatologists, allergists, and all others interested in drug allergy.
