ABSTRACT
Mafenide is a sulfonamide-type topical medication used to treat severe burns. It acts by reducing the bacterial population present in the burn tissue, with particular efficacy against Pseudomonas aeruginosa, and is said to promote healing of deep burns. In pharmaceutical products, mafenide is employed as mafenide acetate. This chapter provides monographs of mafenide which have caused contact allergy/allergic contact dermatitis. The monographs present: identification section; contact allergy (general population, patients with dermatitis, case reports and case series); cross-reactions; patch test sensitization; photocontact allergy; and immediate contact reactions (contact urticaria). The identification section presents IUPAC names, synonyms, CAS and EC numbers, structural and chemical formulas, Merck Index monographs, and advises on patch testing. The chapter also covers an extensive amount of information to benefit dermatologists, allergists, and all others interested in drug allergy.
