ABSTRACT
Methyl nicotinate is the methyl ester of nicotinic acid that is used as an active ingredient, a rubefacient and counter- irritant in over-the-counter topical preparations indicated for the temporary relief of aches and pains in muscles, tendons, and joints. The action of methyl nicotinate as a rubefacient is thought to involve peripheral vasodilation. This chapter provides monographs of methyl nicotinate which have caused contact allergy/allergic contact dermatitis. The monographs present: identification section and contact allergy (general population, patients with dermatitis, case reports and case series). The identification section presents IUPAC names, synonyms, CAS and EC numbers, structural and chemical formulas, Merck Index monographs, and advises on patch testing. The chapter also covers an extensive amount of information to benefit dermatologists, allergists, and all others interested in drug allergy.
