ABSTRACT
In many countries, methyl salicylate is available as an analgesic, anti-inflammatory agent, rubefacient and counterirritant in a wide range of over-the-counter liniments, ointments, lotions and medical oils for muscle pains. Results of studies testing methyl salicylate in consecutive patients suspected of contact dermatitis (routine testing) and those of testing in groups of selected patients. In routine testing in the late 1970s and early 1980s, the percentage of positive reactions to methyl salicylate was decreasing in Hamburg, Germany. Patch testing to the constituents of the ointment gave a positive reaction to methyl salicylate 2% in olive oil. The manufacturer provided samples of the ingredients and patch testing showed a positive reaction to methyl salicylate 2% in olive oil. Cross-reactions have been observed to phenyl salicylate, benzyl salicylate and sodium salicylate.
