ABSTRACT
Metipranolol is a β- adrenergic antagonist effective for both β1- and β2- receptors that has antiarrhythmic, antihypertensive, and antiglaucoma properties. Metipranolol is indicated in the treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma. Metipranolol is used in eye drops as metipranolol hydrochloride. In Leuven, Belgium, in the period 1990-2014, iatrogenic contact dermatitis was diagnosed in 2600 individuals (17% of the total patch test population) 96% of all positive patch test reactions to topical drugs and antiseptics were considered to be relevant. Metipranolol (5% water) was tested in 13 patients and there were 3 positive reactions to it. A patient sensitized to metipranolol was patch tested with a series of other beta-blockers and had a positive reaction only to l-penbutolol sulfate, to which she had most likely not been exposed before and consequently may represent a cross-reaction.
