ABSTRACT
Antazoline is an ethylenediamine derivative with histamine H1 antagonistic, anticholinergic and sedative properties. It is used to relieve nasal congestion. It is also formulated as eye drops with naphazoline to relieve allergic conjunctivitis. In pharmaceutical products, antazoline is employed as antazoline phosphate or as antazoline sulfate. A 53-year-old woman presented with photophobia and diplopia with erythema, edema, and itching of the eyelids. Previously, she had used antazoline 5% eye drops without problems, but now they caused a marked exacerbation of all symptoms and an extension of the dermatitis and conjunctivitis. A 54-year-old woman complained of swelling and redness of the eyelids. Antazoline eye drops were prescribed and the inflammation subsided in 4 days. Patch tests were positive to antazoline, pyribenzamine and various other antihistamines. The maculopapular rash was probably systemic contact dermatitis caused by oral tripelennamine.
