ABSTRACT
Naftifine is a synthetic allylamine derivate with broad-spectrum antifungal activity. It can be fungicidal or fungistatic depending on the concentration and the organisms involved. Naftifine is indicated for the topical treatment of tinea pedis, tinea cruris, and tinea corporis caused by the organisms Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton tonsurans and Epidermophyton floccosum. Naftifine is also effective against gram-negative and gram-products, positive bacteria and has anti-inflammatory activity by targeting the prostaglandin pathway. A 56-year-old woman had treated onychomycosis of the left great toe with naftifine HCl cream for 10 months. Two months before consultation an itchy and burning rash on the left foot appeared. Physical examination showed an eczematous, scaly dermatitis with some fissuring on her left foot and between the toes. Patch testing with the naftifine cream and some of its components yielded a positive (+) reaction to the cream. A 34-year-old atopic man was prescribed naftifine HCl solution for an erythematous dermatitis on the abdomen and genitals.
